However, if you want to uninstall a problem causing program in Safe Mode, normally you can’t without a registry tweak. This is because, in safe mode Windows starts in a limited state, so the required Windows Installer service isn’t started so most programs can’t be uninstalled. SafeMSI.exe is a tiny potable tool designed to uninstall programs very easily in safe mode. This utility will do a registry tweak and launch the Windows Installer service with a click. If you want to uninstall a program in safe mode (You can enter into Safe Mode by pressing F8 key when the computer boots up), just run the tool SafeMSI.exe in Safe Mode, you don’t need to edit the risky registry by hand. SafeMSI.exe is compatible with Windows 2000, XP, Vista and 7 and can be downloaded it free at source. [Via]